Adaphostin
Cat. No.:YN270716
CAS No. :241127-58-2
产品名称: | Adaphostin |
CAS No.: | 241127-58-2 |
Chemical Name: | 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoic Acid Tricyclo[3.3.1.13,7]dec-1-yl Ester; NSC 680410; |
Synonyms: | NSC 680410 |
分子量: | 393.47548699379 |
分子式: | C24H27NO4 |
SMILES: | OC1=CC=C(O)C(CNC2=CC=C(C(OC34CC5CC(C3)CC(C5)C4)=O)C=C2)=C1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Adaphostin (NSC 680410),是 AG957 金刚烷酯,是一种有效的p210bcr/abl抑制剂 (IC50=14 μM)。Adaphostin 诱导 T 淋巴细胞白血病细胞系凋亡 (IC50范围为 17-216 nM)。Adaphostin 对慢性和急性髓系白血病细胞具有显著的选择性活性。Adaphostin 增加了 CLL B 细胞内活性氧 (ROS) 的水平。 |
IC50和靶点: | |
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Fer, N., et al.: J. Exp. Clin. Cancer Res., 29, 91 (2010), Long, J., et al.: Cancer Chemother. Pharmacol. 59, 527 (2007), Mukhopadhyay, I., et al.: J. Biol. Chem. 281, 37330 (2006),