SY-5609
Cat. No.：YN270718
CAS No. ：2417302-07-7
| 产品名称: | SY-5609 |
| CAS No.: | 2417302-07-7 |
| Chemical Name: | |
| Synonyms: | CDK7-IN-3 |
| 分子量: | 490.46 |
| 分子式: | C23H26F3N6OP |
| SMILES: | N#CC1=C(P(C)(C)=O)C2=C(C=C1)C(C3=NC(N[C@@H]4CNC(C)(C)CC4)=NC=C3C(F)(F)F)=CN2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SY-5609 (CDK7-IN-3) 是一种口服有效的，高选择性，非共价的CDK7抑制剂，KD为 0.065 nM。SY-5609 对CDK2(Ki=2600 nM)，CDK9(Ki=960 nM)，CDK12(Ki=870 nM) 具有较弱的抑制作用。SY-5609 诱导肿瘤细胞凋亡并具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"CDK7:0.065 nM (Kd)"},{name: "CDK2:2600 nM (Ki)"},{name: "CDK9:960 nM (Ki)"},{name: "CDK12:870 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
