GSK778
Cat. No.：YN270720
CAS No. ：2451862-42-1
| 产品名称: | GSK778 |
| CAS No.: | 2451862-42-1 |
| Chemical Name: | |
| Synonyms: | iBET-BD1 |
| 分子量: | 511.61 |
| 分子式: | C30H33N5O3 |
| SMILES: | C12C=C(OC[C@@H]3CNCC3)C(C3=C(C)ON=C3C)=CC1=NC=C1N=C(COC)N([C@@H](C3=CC=CC=C3)C)C1=2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK778 (iBET-BD1) 是一种有效和选择性的BET蛋白BD1溴结构域的抑制剂，IC50值为 75 nM (BRD2BD1)，41 nM (BRD3BD1)，41 nM (BRD4BD1) 和143 nM (BRDTBD1)。GSK778 表型化了 pan-BET抑制剂在癌症模型中的作用。 |
| IC50和靶点: | [{name:"BRD2 BD1:75 nM (IC50)"},{name: "BRD3 BD1:41 nM (IC50)"},{name: "BRD4 BD1:41 nM (IC50)"},{name: "BRDT BD1:143 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
