Sincalide
Cat. No.：YN270723
CAS No. ：25126-32-3
| 产品名称: | Sincalide |
| CAS No.: | 25126-32-3 |
| Chemical Name: | 5-L-methionine-3-10-caerulein |
| Synonyms: | 辛卡利特; Cholecystokinin octapeptide; CCK-8; SQ19844 |
| 分子量: | 1143.3 |
| 分子式: | C49H62N10O16S3 |
| SMILES: | OS(OC1=CC=C(C[C@H](NC([C@@H](N)CC(O)=O)=O)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)C=C1)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sincalide (Cholecystokinin octapeptide, CCK‐8) 是一种速效胆囊收缩素 (CCK) 的氨基酸多肽激素类似物，在胆囊造影术中静脉使用。CCK‐8 是 CCK 的一个主要生物活性片段，它保留了 CCK 的大部分生物活性。可通过注射促进胆囊收缩并帮助诊断胆囊和胰腺疾病。其增加胆汁的分泌，使胆囊收缩并使 Oddi 的括约肌松弛，从而使胆汁排入十二指肠。 |
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Raybould, H.E., and Lloyd, K.C.Integration of postprandial function in the proximal gastrointestinal tract. Role of CCK and sensory pathwaysAnn. N. Y. Acad. Sci.713(1),143-156(1994)
Ondetti, M.A., Pluščec, J., Sabo, E.F., et al.Synthesis of cholecystokinin-pancreozymin. I. The C-terminal dodecapeptideJ. Am. Chem. Soc.92(1),195-199(1970)
Rubin, B., Engel, S.L., Drungis, A.M., et al.Cholecystokinin-like activities in guinea pigs and in dogs of the C-terminal octapeptide (SQ 19,844) of cholecystokininJ. Pharm. Sci.58(8),955-959(1969)
