L-Glutamine-
Cat. No.：YN270738
| 产品名称: | L-Glutamine- |
| CAS No.: | 316371-84-3 |
| Chemical Name: | 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, monopotassium salt |
| Synonyms: | BRL 49653 potassium |
| 分子量: | 395.5 |
| 分子式: | C18H18N3O3S • K |
| SMILES: | CN(CCOC1=CC=C(CC2SC([N-]C2=O)=O)C=C1)C3=NC=CC=C3.[K+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rosiglitazone (BRL 49653) potassium 是一种具有口服活性的PPARγ选择性激动剂 (EC50: 60 nM,Kd: 40 nM)。Rosiglitazone potassium 是一种TRPC5激活剂 (EC50: 30 μM) 和TRPM3抑制剂。Rosiglitazone potassium 可用于肥胖、糖尿病、衰老、卵巢癌的研究。 |
| IC50和靶点: | [{name:"PPARγ:40 nM (Kd)"},{name: "PPARγ:60 nM (EC50)"},{name: "TRPC5:30 μM (EC50)'}, 'TRPM3'] |
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Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., et al.An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)J. Biol. Chem.270(22),12953-12956(1995)
Kim, J.-H., Lewin, T.M., and Coleman, R.A.Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinedionesJ. Biol. Chem.276(27),24667-24673(2001)
Doll, S., Proneth, B., Tyurina, Y.Y., et al.ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid compositionNat. Chem. Biol.13(1),91-98(2017)
Zhou, J.Y., Zhou, S.W., Zhang, K.B., et al.Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic ratsBiol. Pharm. Bull.31(6),1169-1176(2008)
