Sepantronium hydrochloride
Cat. No.：YN270745
CAS No. ：355406-09-6
规格
价格(RMB)
库存
| 产品名称: | Sepantronium hydrochloride |
| CAS No.: | 355406-09-6 |
| Chemical Name: | 4,9-dihydro-3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, monochloride |
| Synonyms: | YM-155 hydrochloride |
| 分子量: | 398.84272 |
| 分子式: | C20H19N4O3 • Cl |
| SMILES: | O=C1C2=C(C(C3=C1N(CCOC)C(C)=[N+]3CC4=NC=CN=C4)=O)C=CC=C2.[Cl-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sepantronium hydrochloride (YM-155 hydrochloride) 是一种新型survivin抑制剂，对survivin启动子的IC50为 0.54 nM。 |
| IC50和靶点: | |
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Nakahara, T., Takeuchi, M., Kinoyama, I., et al.YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenograftsCancer Res.67(17),8014-8021(2007)
Na, Y.S., Yang, S.J., Kim, S.M., et al.YM155 induces EGFR suppression in pancreatic cancer cellsPLoS One7(6),(2012)
Zhao, Y., Du, X., Duan, Y., et al.High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitorsProtein Cell12(11),877-888(2021)
