3-Hydroxykynurenine
Cat. No.：YN270757
CAS No. ：484-78-6
| 产品名称: | 3-Hydroxykynurenine |
| CAS No.: | 484-78-6 |
| Chemical Name: | α,2-diamino-3-hydroxy-γ-oxo-benzenebutanoic acid |
| Synonyms: | 3-Hydroxy-DL-kynurenine |
| 分子量: | 224.21336 |
| 分子式: | C10H12N2O4 |
| SMILES: | OC1=CC=CC(C(CC(N)C(O)=O)=O)=C1N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3-Hydroxykynurenine 是一种色氨酸代谢物，是潜在的内源性神经毒素，在几种神经退行性疾病中表达水平都有升高的现象。3-Hydroxykynurenine 诱导神经细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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Badawy, A.A.-B., and Morgan, C.J.Tryptophan metabolites as potent inhibitors of aldehyde dehydrogenase activity and potential alcoholism-aversion therapeutic agentsInt. Congr. Ser.1304,344-351(2007)
Narui, K., Noguchi, N., Saito, A., et al.Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathwayBiol. Pharm. Bull.32(1),41-44(2009)
Braidy, N., Grant, R., Brew, B.J., et al.Effects of kynurenine pathway metabolites on intracellular NAD+ synthesis and cell death in human primary astrocytes and neuronsInt. J. Tryptophan Res.2,61-69(2009)
