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7,3',4'-Trihydroxyisoflavone

Cat. No.:YN270758

  • CAS No. :485-63-2

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: 7,3',4'-Trihydroxyisoflavone
      CAS No.: 485-63-2
      Chemical Name: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one
      Synonyms:Orita13
      分子量:270.2
      分子式:C15H10O5
      SMILES:OC1=CC=C(C(C(C2=CC(O)=C(O)C=C2)=CO3)=O)C3=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: 7,3',4'-Trihydroxyisoflavone 是黄豆苷元的主要代谢物,是Cot (Tpl2/MAP3K8)和MKK4的 ATP 竞争性抑制剂。7,3',4'-Trihydroxyisoflavone 具有抗癌、抗血管生成、化学保护和自由基清除活性。
      IC50和靶点:
      In Vitro:
      In Vivo:
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    • Komiyama, K., Funayama, S., Anraku, Y., et al.Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces spJ. Antibiot. (Tokyo)42(9),1344-1349(1989)

      Choi, K.-Y., Kim, T.-j., Koh, S.-K., et al.A-ring ortho-specific monohydroxylation of daidzein by cytochrome P450s of Nocardia farcinica IFM10152Biotechnol. J.4(11),1586-1595(2009)

      Yasuda, T., and Ohsawa, K.Urinary metabolites of daidzin orally administered in ratsBiol. Pharm. Bull.21(9),953-957(1998)

      Park, J.-S., Kim, D.H., Lee, J.K., et al.Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitorsBioorg. Med. Chem. Lett.20(3),1162-1164(2010)

      Maekawa, T., Kosuge, S., Sakamoto, S., et al.Biochemical characterization of 60S acidic ribosomal P proteins associated with CK-II from bamboo shoots and potent inhibitors of their phosphorylation in vitroBiol. Pharm. Bull.22(7),667-673(1999)

      Lee, D.E., Lee, K.Q., Song, N.R., et al.7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinaseJ. Biol. Chem.285(28),21458-21466(2010)

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