Cystamine (dihydrochloride)
Cat. No.:YN270764
| 产品名称: | Cystamine (dihydrochloride) | 
| CAS No.: | 56-17-7 | 
| Chemical Name: | 2,2'-dithiobis-ethanamine, dihydrochloride | 
| Synonyms: | Decarboxycystine dihydrochloride, 2-Aminoethyl disulfide dihydrochloride, 2,2'-Dithiobisethanamine dihydrochloride | 
| 分子量: | 225.2 | 
| 分子式: | C4H12N2S2 • 2HCl | 
| SMILES: | NCCSSCCN.Cl.Cl | 
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. | 
| 运输: | Room temperature in continental US; may vary elsewhere. | 
| 产品描述: | Cystamine (dihydrochloride) 是游离硫醇半胱胺的二硫化物形式。Cystamine 是一种转谷氨酰胺酶 (Tgase) 抑制剂,具有口服活性。Cystamine 对 caspase-3 也有抑制活性,IC50值为 23.6 μM。Cystamine 可用于亨廷顿舞蹈病(HD)等多种疾病的研究。 | 
| IC50和靶点: | [{name:"Caspase 3:23.6 μM (IC50)"}] | 
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: | 
Siegel, M., and Khosla, C.Transglutaminase 2 inhibitors and their therapeutic role in disease statesPharmacol. Ther.115(2),232-245(2007)
Caccamo, D., Currò, M., and Ientile, R.Potential of transglutaminase 2 as a therapeutic targetExpert Opin. Ther. Targets14(9),989-1003(2010)
Smethurst, P.A., and Griffin, M.Measurement of tissue transglutaminase activity in a permeabilized cell system: Its regulation by Ca2+ and nucleotidesBiochem. J.313(pt 3),803-808(1996)
Dedeoglou, A., Kubilus, J.K., Jeitner, T.M., et al.Therapeutic effects of cystamine in a murine model of Huntington's diseaseJ. Neurosci.22(20),8942-8950(2002)
Borrell-Pagès, M., Canals, K.P., Cordelièrs, F.P., et al.Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminaseJ. Clin. Invest.116(5),1410-1424(2006)
Elli, L., Ciulla, M.M., Busca, G., et al.Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel diseaseLab. Invest.91(3),452-461(2011)