MIRA-1
Cat. No.：YN270774
CAS No. ：72835-26-8
规格
价格(RMB)
库存
| 产品名称: | MIRA-1 |
| CAS No.: | 72835-26-8 |
| Chemical Name: | 1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione |
| Synonyms: | NSC 19630 |
| 分子量: | 183.2 |
| 分子式: | C8H9NO4 |
| SMILES: | O=C1C=CC(N1COC(CC)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MIRA-1 是一种马来酰亚胺类似物。MIRA-1 可通过恢复p53依赖的转录转激活诱导 p53 突变细胞凋亡 (apoptosis)。MIRA-1 具有抗肿瘤活性。 |
| IC50和靶点: | |
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Bykov, V.J.N., Issaeva, N., Zache, N., et al.Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogsJ. Biol. Chem.280(34),30384-30391(2005)
Saha, M.N., Chen, Y., Chen, M.H., et al.Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agentsBr. J. Cancer110(9),2224-2231(2014)
