ARN5187 trihydrochloride
Cat. No.：YN270782
CAS No. ：864420-54-2
规格
价格(RMB)
库存
| 产品名称: | ARN5187 trihydrochloride |
| CAS No.: | 864420-54-2 |
| Chemical Name: | N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine |
| Synonyms: | NAE-IN-M22 |
| 分子量: | 363.32344 |
| 分子式: | C20H24Cl2N2 |
| SMILES: | ClC1=CC=C(CCNC2CCN(CC2)CC3=CC=CC=C3)C(Cl)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NAE-IN-M22 是一种有效，选择性和可逆的NEDD8活化酶 (NAE) 抑制剂，效力在微摩尔范围内。NAE-IN-M22 抑制多种癌细胞生长并诱导 A549 细胞凋亡。NAE-IN-M22 还可以在体内抑制肿瘤的生长。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lu, P., Liu, X., Yuan, X., et al.Discovery of a novel NEDD8 activating enzyme inhibitor with piperidin-4-amine scaffold by structure-based virtual screeningACS Chem. Biol.11(7),1901-1907(2016)
