MK-3903
Cat. No.：YN420059
CAS No. ：1219737-12-8
规格
价格(RMB)
库存
| 产品名称: | MK-3903 |
| CAS No.: | 1219737-12-8 |
| Chemical Name: | 5-[(5-[1,1′-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl-benzoic acid |
| Synonyms: | MK 3903 |
| 分子量: | 454.90 |
| 分子式: | C₂₇H₁₉ClN₂O₃ |
| SMILES: | ClC1=CC2=C(NC(OC3=CC=C(C)C(C(O)=O)=C3)=N2)C=C1C(C=C4)=CC=C4C5=CC=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-3903 是一种有效且有选择性的 AMP 激活的蛋白激酶 (AMPK) 激活剂，其EC50值为 8 nM。 |
| IC50和靶点: | [{name:"AMPK:8 nM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lan, P., Romero, F.A., Wodka, D., et al.Hit-to-lead optimization and discovery of 5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid (MK-3903): A novel class of benzimidazole-based activators of AMP-activated protein kinaseJ. Med. Chem.60(21),9040-9052(2017)
