VUF10460
Cat. No.：YN320145
CAS No. ：1028327-66-3
| 产品名称: | VUF10460 |
| CAS No.: | 1028327-66-3 |
| Chemical Name: | 4-(4-methyl-1-piperazinyl)-6-phenyl-2-pyrimidinamine |
| Synonyms: | VUF 10460,VUF-10460 |
| 分子量: | 269.34 |
| 分子式: | C₁₅H₁₉N₅ |
| SMILES: | NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VUF10460是非咪唑组胺H4受体激动剂; 与大鼠H4受体结合的pKi值为7.46。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Cowart, M.D., Altenbach, R.J., Liu, H., et al.Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: A new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation modelsJ. Med. Chem.51(20),6547-6557(2008)
Coruzzi, G., Adami, M., Pozzoli, C., et al.Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomachEur J. Pharmacol.669(1-3),121-127(2011)
