Carebastine
Cat. No.：YN320548
CAS No. ：90729-42-3
| 产品名称: | Carebastine |
| CAS No.: | 90729-42-3 |
| Chemical Name: | 4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl-benzeneacetic acid |
| Synonyms: | |
| 分子量: | 499.64 |
| 分子式: | C₃₂H₃₇NO₄ |
| SMILES: | O=C(CCCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C4=CC=C(C=C4)C(C)(C(O)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Carebastine 是 Ebastine 的活性代谢产物。Carebastine 是一种组胺 H1 受体拮抗剂。Carebastine 抑制 VEGF 诱导的 HUVEC 和 HPAEC 增殖，迁移和血管生成。Carebastine 可抑制巨噬细胞移动抑制因子的表达。 |
| IC50和靶点: | |
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Vincent, J., Liminana, R., Meredith, P.A., et al.The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjectsBr. J. Clin. Pharmacol.26(5),497-502(1988)
Liu, K.-H., Kim, M.-G., Lee, D.-J., et al.Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: Major roles for CYP2J2 and CYP3ADrug. Metab. Dispos.34(11),1793-1797(2006)
Hishinuma, S., Kosaka, K., Akatsu, C., et al.Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H1 receptors by Na+Biochem. Pharmacol.128,46-54(2017)
Yaku, I., Ishii, K., Seto, Y., et al.Pharmacological study of ebastine, a novel histamine H1-receptor antagonistNihon Yakurigaku Zasshi103(3),121-135(1994)
Yamauchi, Y., Fujikura, T., and Shimosawa, T.The effect of H1 antagonists carebastine and olopatadine on histamine induced expression of CC chemokines in cultured human nasal epithelial cellsAllergol. Int.56(2),171-177(2007)
