GSK189254A
Cat. No.：YN320817
CAS No. ：720690-73-3
| 产品名称: | GSK189254A |
| CAS No.: | 720690-73-3 |
| Chemical Name: | 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide |
| Synonyms: | GSK189254 |
| 分子量: | 351.44 |
| 分子式: | C₂₁H₂₅N₃O₂ |
| SMILES: | O=C(NC)C(C=N1)=CC=C1OC2=CC(CC3)=C(C=C2)CCN3C4CCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK189254A (GSK189254)是一个新颖高效有选择性的H3受体拮抗剂，对人类和大鼠H3的pKi值分别为9.59-9.90 and 8.51-9.17。 |
| IC50和靶点: | |
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Medhurst, A.D., Atkins, A.R., Beresford, I.J., et al.GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical modelsJ. Pharmacol. Exp. Ther.321(3),1032-1045(2007)
Hsieh, G.C., Honore, P., Pai, M., et al.Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systemsBrain Res.1354,74-84(2010)
