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Azatadine dimaleate

Cat. No.:YN321407

  • CAS No. :3978-86-7

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    • 产品名称: Azatadine dimaleate
      CAS No.: 3978-86-7
      Chemical Name: 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, (2Z)-2-butenedioate
      Synonyms:马来酸阿扎他定; Azatadine maleate
      分子量:522.55
      分子式:C₂₈H₃₀N₂O₈
      SMILES:O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=CC=CN=C4\2
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Azatadine马来酸氢盐是组胺受体和胆碱受体抑制剂,IC50分别为6.5 nM和10 nM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Barnett, A., Iorio, L.C., Kreutner, W., et al.Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamineAgents Actions43(3-4),149-156(1994)

      Tozzi, S., Roth, F.E., and Tabachnick, I.I.A.The pharmacology of azatadine, a potential antiallergy drugAgents Actions4(4),264-270(1974)

      Piwinski, J.J., Wong, J.K., Green, M.J., et al.Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-llH-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-y1idene)piperidinesJ. Med. Chem.34(1),457-461(1991)

      Baroody, F.M., and Naclerio, R.M.Antiallergic effects of H1-receptor antagonistsAllergy55(Suppl 64),17-27(2000)

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