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BAY 11-7085

Cat. No.:YN410007

  • CAS No. :196309-76-9

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    • 产品名称: BAY 11-7085
      CAS No.: 196309-76-9
      Chemical Name: 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile
      Synonyms:BAY 11-7083
      分子量:249.33
      分子式:C₁₃H₁₅NO₂S
      SMILES:N#C/C=C/S(C(C=C1)=CC=C1C(C)(C)C)(=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: BAY 11-7085 (BAY 11-7083) 是NF-κB激活和IκBα磷酸化的抑制剂,稳定 IκBα 的IC50值为 10 μM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Wajant, H., and Scheurich, P.TNFR1-induced activation of the classical NF-κB pathwayFEBS J.278(6),862-876(2011)

      Pierce, J.W., Schoenleber, R., Jesmok, G., et al.Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivoJ. Biol. Chem.272(34),21096-21103(1997)

      Scaife, C.L., Kuang, J., Wills, J.C., et al.Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: Implications for metastasisCancer Res.62(23),6870-6878(2002)

      Di Giuseppe, M., Gambelli, F., Hoyle, G.W., et al.Systemic inhibition of NF-κB activation protects from silicosisPLoS One4(5),e5689(2009)

      Hu, X., Janssen, W.E., Moscinski, L.C., et al.An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanismCancer Res.61(16),6290-6296(2001)

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