Nimbolide
Cat. No.：YN410023
CAS No. ：25990-37-8
| 产品名称: | Nimbolide |
| CAS No.: | 25990-37-8 |
| Chemical Name: | 8-(3-furanyl)-2aR,5aR,6S,6aR,8R,9,9aR,10aS,10bR,10cR-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-2H,5H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, methyl ester |
| Synonyms: | 印苦楝内酯 |
| 分子量: | 466.52 |
| 分子式: | C₂₇H₃₀O₇ |
| SMILES: | CC1=C2[C@]([H])(O[C@]([H])([C@]3(C4[C@@]5(C(C=C[C@]4(C(O3)=O)C)=O)C)[H])[C@@]2([C@@H]5CC(OC)=O)C)CC1C6=COC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nimbolide 是一种源自Azadirachta indicaL 叶和花的三萜化合物。Nimbolide 通过抑制NF-κB而诱导肿瘤细胞凋亡。 Nimbolide 抑制CDK4/CDK6激酶活性。Nimbolide 抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。 |
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Subramani, R., Gonzalez, E., Arumugam, A., et al.Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transitionSci. Rep.6:19819,(2016)
