Laquinimod
Cat. No.：YN410037
CAS No. ：248281-84-7
| 产品名称: | Laquinimod |
| CAS No.: | 248281-84-7 |
| Chemical Name: | 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide |
| Synonyms: | 拉喹莫德; ABR-215062 |
| 分子量: | 356.80 |
| 分子式: | C₁₉H₁₇ClN₂O₃ |
| SMILES: | O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2Cl)N(CC)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Laquinimod是一种有效的免疫调节剂，可预防中枢神经系统的神经变性和炎症。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Brunmark, C., Runström, A., Ohlsson, L., et al.The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis.J. Neuroimmunol.130(1-2),163-172(2002)
Gurevich, M., Gritzman, T., Orbach, R., et al.Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression studJ. Neuroimmunol.221(1-2),87-94(2010)
Wegner, C.D., Stadelmann, C., Pförtner, R., et al.Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitisJ. Neuroimmunol.227(1-2),133-143(2010)
Pitarokoili, K., Ambrosius, B., Schrewe, L., et al.Laquinimod exerts strong clinical and immunomodulatory effects in Lewis rat experimental autoimmune neuritisJ. Neuroimmunol.274(1-2),38-45(2014)
Kaye, J., Piryatinsky, V., Birnberg, T., et al.Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptorProc. Natl. Acad. Sci. USA113(41),E6145-E6152(2016)
