QNZ
Cat. No.：YN410057
CAS No. ：545380-34-5
| 产品名称: | QNZ |
| CAS No.: | 545380-34-5 |
| Chemical Name: | N4-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine |
| Synonyms: | EVP4593 |
| 分子量: | 356.42 |
| 分子式: | C₂₂H₂₀N₄O |
| SMILES: | NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | QNZ (EVP4593) 强抑制NF-κB转录激活和TNF-α产生，IC50分别为 11 和 7 nM。QNZ (EVP4593) 是一种保护神经的钙池操纵的钙通道 (SOC) 抑制剂。 |
| IC50和靶点: | [{name:"NF-κB:11 nM (IC50, in human Jurkat cells transfected with pNFκB-Luc)"}] |
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| Solvent & Solubility: |
Karin, M., Yamamtoto, Y., and Wang, Q.M.The IKK NF-κB system: A treasure trove for drug developmentNat. Rev. Drug Discov.3(1),17-26(2004)
Tobe, M., Isobe, Y., Tomizawa, H., et al.Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activationBioorg. Med. Chem.11(3),383-391(2003)
