JSH-23
Cat. No.：YN410059
CAS No. ：749886-87-1
| 产品名称: | JSH-23 |
| CAS No.: | 749886-87-1 |
| Chemical Name: | 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine |
| Synonyms: | 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE;JSH-23;LogP;4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine;4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine;B Activation Inhibitor II, JSH-23;JSH 23;NF-κ4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;AK1 |
| 分子量: | 240.34 |
| 分子式: | C₁₆H₂₀N₂ |
| SMILES: | NC1=CC(C)=CC=C1NCCCC2=CC=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JSH-23 是NF-κB抑制剂，作用于脂多糖刺激的巨噬细胞 RAW 264.7，抑制 NF-κB 转录活性，IC50为 7.1 μM。JSH-23 抑制 NF-κB p65 的核易位而不影响 IκBα 降解。 |
| IC50和靶点: | [{name:"NF-κB:7.1 μM (IC50, in RAW 264.7 cells)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Shin, H.M., Kim, M.H., Kim, B.H., et al.Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-κB without affecting IκB degradationFEBS Lett.571(1-3),50-54(2004)
Ahmed, K.M., Zhang, H., and Park, C.C.NF-κB regulates radioresistance mediated by β1-integrin in three-dimensional culture of breast cancer cellsCancer Res.73(12),3737-3748(2013)
Kumar, A., Negi, G., and Sharma, S.S.JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: Effect on neuroinflammation and antioxidant defenceDiabetes Obes. Metab.13(8),750-758(2011)
Koo, J.W., Russo, S.J., Ferguson, D., et al.Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behaviorProc. Natl. Acad. Sci. USA107(6),2669-2674(2010)
