Andrographolide
Cat. No.：YN410094
CAS No. ：5508-58-7
| 产品名称: | Andrographolide |
| CAS No.: | 5508-58-7 |
| Chemical Name: | 3E-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4S-hydroxy-2(3H)-furanone |
| Synonyms: | 穿心莲内酯; Andrographis |
| 分子量: | 350.45 |
| 分子式: | C₂₀H₃₀O₅ |
| SMILES: | O=C1OC[C@@H](O)/C1=C\C[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Andrographolide 是一种NF-κB抑制剂，通过共价修饰内皮细胞中p50的半胱氨酸残基而抑制 NF-κB 活化，而不影响 IκBα 降解或 p50/p65 核易位。Andrographolide 具有抗病毒作用。 |
| IC50和靶点: | |
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Jarukamjorn, K., and Nemoto, N.Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolideJ. Health Sci.54(4),370-381(2008)
Varma, A., Padh, H., and Shrivastava, N.Andrographolide: A new plant-derived antineoplastic entity on horizonEvid. Based Complement. Alternat. Med.2011,1-9(2011)
Xia, Y.F., Ye, B.Q., Li, Y.D., et al.Andrographolide attenuates inflammation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50J. Immunol.173(6),4207-4217(2004)
