cis-Lomibuvir
Cat. No.：YN1590006
| 产品名称: | cis-Lomibuvir |
| CAS No.: | 1026785-59-0 |
| Chemical Name: | 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid |
| Synonyms: | cis-VX-222 |
| 分子量: | 445.61574 |
| 分子式: | C25H35NO4S |
| SMILES: | O[C@@H]1CC[C@H](N(C([C@@H]2CC[C@@H](C)CC2)=O)C3=C(C(O)=O)SC(C#CC(C)(C)C)=C3)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | cis-Lomibuvir (cis-VX-222) 是 Lomibuvir 的顺式异构体。Lomibuvir (VX-222) 是一种选择性的非核苷聚合酶抑制剂，靶向丙型肝炎病毒 NS5B 聚合酶 (RdRp) 的拇指口袋 2，Kd为 17 nM。Lomibuvir 抑制 1b/Con1 型HCV亚基因组复制子，EC50为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yi, G., Deval, J., Fan, B., et al.Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvirAntimicrob. Agents Chemother.56(2),830-837(2012)
