4-Hydroxyestrone
Cat. No.：YN1730147
CAS No. ：3131-23-5
| 产品名称: | 4-Hydroxyestrone |
| CAS No.: | 3131-23-5 |
| Chemical Name: | 3,4-dihydroxy-estra-1,3,5(10)-trien-17-one |
| Synonyms: | 4-羟基雌酮; 4-OHE1 |
| 分子量: | 286.36548 |
| 分子式: | C18H22O3 |
| SMILES: | C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C(O)=C4CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4-Hydroxyestrone (4-OHE1) 是一种雌酮代谢物，对氧化神经毒性具有很强的神经保护作用。4-Hydroxyestrone 增加了由SIRT1介导的 p53 去乙酰化导致的 p53 的细胞质易位。4-Hydroxyestrone 几乎没有雌激素活性 |
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Cribb, A.E., Knight, M.J., Dryer, D., et al.Role of polymorphic human cytochrome P450 enzymes in estrone oxidationCancer Epidemiol. Biomarkers Prev.15(3),551-558(2006)
Choi, H.J., Lee, A.J., Kang, K.S., et al.4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damageSci. Rep.10(1),7283(2020)
Seeger, H., Huober, J., Wallwiener, D., et al.Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifenHorm. Metab. Res.36(5),277-280(2004)
