(-)-(E)-Guggulsterone
Cat. No.：YN1720063
CAS No. ：39025-24-6
| 产品名称: | (-)-(E)-Guggulsterone |
| CAS No.: | 39025-24-6 |
| Chemical Name: | pregna-4-17(20)-diene-3,16-dione |
| Synonyms: | |
| 分子量: | 312.5 |
| 分子式: | C21H28O2 |
| SMILES: | O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC(/C4=C\C)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (-)-(E)-Guggulsterone 是 Z-guggulsterone 的代谢物。Guggulsterone 是 guggulipid 的活性成分，guggulipid 是一种源自 Commiphora mukul 的阿育吠陀活性分子。Guggulsterone 具有降血脂活性。 |
| IC50和靶点: | |
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Makishima, M., Okamoto, A.Y., Repa, J.J., et al.Identification of a nuclear receptor for bile acidsScience284,1362-1365(1999)
Barbier, O., Torra, I.P., Sirvent, A., et al.FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activityGastroenterology124,1926-1940(2003)
Tan, K.P., Yang, M., and Ito, S.Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stressMol. Pharmacol.72(5),1380-1390(2007)
Urizar, N.L., Liverman, A.B., Dodds, D.T., et al.A natural product that lowers cholesterol as an antagonist ligand for FXRScience296(5573),1703-1706(2002)
Cui, J., Huang, L., Zhao, A., et al.Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pumpJ. Biol. Chem.278(12),10214-10220(2003)
Wu, J., Xia, C., Meier, J., et al.The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptorMol. Endocrinol.16(7),1590-1597(2002)
