CGP7930
Cat. No.：YN1730151
| 产品名称: | CGP7930 |
| CAS No.: | 57717-80-3 |
| Chemical Name: | 3,5-bis(1,1-dimethylethyl)-4-hydroxy-β,β-dimethyl-benzenepropanol |
| Synonyms: | CGP7930; CGP-7930; CGP 7930. |
| 分子量: | 292.45618 |
| 分子式: | C19H32O2 |
| SMILES: | CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CC(C)(C)CO)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGP7930 (3-(3',5'-Di-tert-butyl-4'-hydroxy)phenyl-2,2-dimethylpropanol) 是一种代谢型GABAB受体变构正向调节剂。CGP7930 增强 l-baclofen 对培养的皮层神经元振荡活动的抑制作用。 |
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Urwyler, S., Mosbacher, J., Lingenhoehl, K., et al.Positive allosteric modulation of native and recombinant γ-aminobutyric acidB receptors by 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501Mol. Pharmacol.60(5),963-971(2001)
Chen, Y., Phillips, K., Minton, G., et al.GABAB receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental areaBr. J. Pharmacol.144(7),926-932(2005)
Carai, M.A.M., Colombo, G., Froestl, W., et al.In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptorEur. J. Pharmacol.504(3),213-216(2004)
Adams, C.L., and Lawrence, A.J.CGP7930: A positive allosteric modulator of the GABAB receptorCNS Drug Rev.13(3),308-316(2007)
Orrù, A., Lai, P., Lobina, C., et al.Reducing effect of the positive allosteric modulators of the GABAB receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring ratsEur. J. Pharmacol.525(1-3),105-111(2005)
