Alpidem
Cat. No.：YN1730159
| 产品名称: | Alpidem |
| CAS No.: | 82626-01-5 |
| Chemical Name: | 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide |
| Synonyms: | Ananxyl |
| 分子量: | 404.33234 |
| 分子式: | C21H23Cl2N3O |
| SMILES: | O=C(CC1=C(C2=CC=C(C=C2)Cl)N=C3C=CC(Cl)=CN31)N(CCC)CCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Alpidem 选择性结合含有α1β2γ2亚单位的GABAA受体，其IC50为 17 nM，具有抗焦虑作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
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Faure-Halley, C., Graham, D., Arbilla, S., et al.Expression and properties of recombinant α1β2γ2 and α5β2γ2 forms of the rat GABAA receptorEur. J. Pharmacol.246(3),283-287(1993)
Trapani, G., Franco, M.C., Ricciardi, L., et al.Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral typeJ. Med. Chem.40(19),3109-3118(1997)
Zivkovic, B., Morel, E., Joly, D., et al.Pharmacological and behavioral profile of alpidem as an anxiolyticPharmacopsychiatry23(Suppl. 3),108-113(1990)
Hascoët, M., and Bourin, M.Anticonflict effect of alpidem as compared with the benzodiazepine alprazolam in ratsPharmacol. Biochem. Behav.56(2),317-324(1997)
