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Acivicin

Cat. No.：42228-92-2

  • CAS No. ：42228-92-2

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    • 产品名称: Acivicin
      CAS No.: 42228-92-2
      Chemical Name:
      Synonyms:阿西维辛; AT-125; U-42126
      分子量:178.57
      分子式:C₅H₇ClN₂O₃
      SMILES:ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Tso, J.Y., Bower, S.G., and Zalkin, H.Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(αS, 5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125)J. Biol. Chem.255(14),6734-6738(1980)', 'Lyons, S.D., Sant, M.E., and Christopherson, R.I.Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemiaJ. Biol. Chem.265(19),11377-11381(1990)', 'Stole, E., Smith, T.K., Manning, J.M., et al.Interaction of γ-glutamyl transpeptidase with acivicinJ. Biol. Chem.269(34),21435-21439(1994)', 'Smith, T.K., Ikeda, Y., Fujii, J., et al.Different sites of acivicin binding and inactivation of γ-glutamyl transpeptidasesProc. Natl. Acad. Sci. USA92,2360-2364(1995)', 'Griffith, O.W., and Meister, A.Excretion of cysteine and γ-glutamylcysteine moieties in human and experimental animal γ-glutamyl transpeptidase deficiencyProc. Natl. Acad. Sci. USA77(6),3384-3387(1980)', 'Meck, R.A., Clubb, K.J., Allen, L.M., et al.Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, acivicin (NSC 163501)Cancer Res.41,4547-4553(1981)', 'Willoughby, L.F., Schlosser, T., Manning, S.A., et al.An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discoveryDis. Model. Mech.6(2),521-529(2012)
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