Aurora Kinase Inhibitor 3
Cat. No.：YN290130
CAS No. ：879127-16-9
规格
价格(RMB)
库存
| 产品名称: | Aurora Kinase Inhibitor 3 |
| CAS No.: | 879127-16-9 |
| Chemical Name: | N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-cyclopropanecarboxamide |
| Synonyms: | Aurora Kinase Inhibitor III |
| 分子量: | 413.40 |
| 分子式: | C₂₁H₁₈F₃N₅O |
| SMILES: | O=C(C1CC1)NC2=CC=CC(NC3=NC=CC(NC4=CC=CC(C(F)(F)F)=C4)=N3)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aurora Kinase Inhibitor 3 是一种有效的，选择性Aurora A 激酶抑制剂，IC50为 42 nM，同时微弱抑制 EGFR，IC50>10 μM。Aurora Kinase Inhibitor 3 的环丙烷羧酸部分指向 ATP 结合口袋的溶剂暴露区域，并且与其他公开的 AIK 结构相比，活性位点中存在几种诱导的结构变化。 |
| IC50和靶点: | [{name:"Aurora A:42 nM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Zhang, Q., Liu, Y., Gao, F., et al.Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle libraryJ. Am. Chem. Soc.128(7),2182-2183(2006)
