Midostaurin

Cat. No.：120685-11-2

CAS No. ：120685-11-2

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5mg

￥1710

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10mg

￥2736

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50mg

￥7125

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100mg

￥11400

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200mg

￥11400

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500mg

￥11400

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产品名称:	Midostaurin
CAS No.:	120685-11-2
Chemical Name:
Synonyms:	米哚妥林; PKC412; CGP 41251
分子量:	570.64
分子式:	C₃₅H₃₀N₄O₄
SMILES:	O=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

Fabbro, D., Buchdunger, E., Wood, J., et al.Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agentPharmacol. Ther.82(2-3),293-301(1999)', 'Ozaki, H., Seo, M.S., Ozaki, K., et al.Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularizationAm. J. Pathol.156(2),697-707(2000)', "Tenzer, A., Zingg, D., Rocha, S., et al.The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase CCancer Res.61(22),8203-8210(2001)", 'Andrejauskas-Buchdunger, E., and Regenass, U.Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251Cancer Res.52(19),5353-5358(1992)', 'Li, H., Hergert, S.M., Schäfer, S.C., et al.Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouseNitric Oxide12(4),231-236(2005)', 'Marmy-Conus, N., Hannan, K.M., and Pearson, R.B.Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k: Implications for the analysis of S6K signallingFEBS Lett.519(1-3),135-140(2002)', 'El Fitori, J., Su, Y., Büchler, P., et al.PKC412 small-molecule tyrosine kinase inhibitor: Single-compound therapy for pancreatic cancerCancer110(7),1457-1468(2007)