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Sotrastaurin

Cat. No.：425637-18-9

  • CAS No. ：425637-18-9

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    • 产品名称: Sotrastaurin
      CAS No.: 425637-18-9
      Chemical Name:
      Synonyms:AEB071
      分子量:438.48
      分子式:C₂₅H₂₂N₆O₂
      SMILES:O=C(C(C1=C2C=CC=CC2=NC(N3CCN(C)CC3)=N1)=C4C5=CNC6=C5C=CC=C6)NC4=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Evenou, J.P., Wagner, J., Zenke, G., et al.The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activationJ. Pharmacol. Exp. Ther.330(3),792-801(2009)', 'Vafadari, R., Kraaijeveld, R., Weimar, W., et al.Tacrolimus inhibits NF-κB activation in peripheral human T cellsPLoS One8(4),e60784(2014)', 'Skvara, H., Dawid, M., Kleyn, E., et al.The PKC inhibitor AEB071 may be a therapeutic option for psoriasisJ. Clin. Invest.118(9),3151-3159(2008)', 'Hardinger, K.L., and Brennan, D.C.Novel immunosuppressive agents in kidney transplantationWorld J. Transplant.3(4),68-77(2013)', 'Verkaar, F., Blankesteijn, W.M., Smits, J.F.M., et al.β-Galactosidase enzyme fragment complementation for the measurement of Wnt/β-catenin signalingFASEB J.24(4),1205-1217(2010)', 'Verkaar, F., van der Stelt, M., Blankesteijn, W.M., et al.Discovery of novel small molecule activators of β-catenin signalingPLoS One6(4),e19185(2011)
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