R 59-022

Cat. No.：93076-89-2

CAS No. ：93076-89-2

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5mg

￥2945

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￥4655

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产品名称:	R 59-022
CAS No.:	93076-89-2
Chemical Name:
Synonyms:	DKGI-I; Diacylglycerol kinase inhibitor I
分子量:	459.58
分子式:	C₂₇H₂₆FN₃OS
SMILES:	O=C1C(CCN(CC/2)CCC2=C(C3=CC=CC=C3)/C4=CC=C(F)C=C4)=C(C)N=C5N1C=CS5
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

Topham, M.K., and Prescott, S.M.Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functionsJ. Biol. Chem.274(17),11447-11450(1999)', 'de Chaffoy de Courcelles, D.C., Roevens, P., and Van Belle, H.R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact plateletJ. Biol. Chem.260(29),15762-15770(1985)', 'Nunn, D.L., and Watson, S.P.A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human plateletsBiochem. J.243(3),809-813(1987)', 'Nobe, K., Miyatake, M., Nobe, H., et al.Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced enhancement of mouse portal vein contraction under high glucose conditionsBr. J. Pharmacol.143(1),166-179(2004)', 'Dominguez, C.L., Floyd, D.H., Xiao, A., et al.Diacylglycerol kinase a is a critical signaling node and novel therapeutic target in glioblastoma and other cancersCancer Discov.3(7),782-797(2013)', 'Tu-Sekine, B., Goldschmidt, H., Petro, E., et al.Diacylglycerol kinase θ: Regulation and stabilityAdv. Biol. Regul.53(1),118-126(2013)', 'Gómez-Merino, F.C., Arana-Ceballos, F.A., Trejo-Téllez, L.I., et al.Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration: The DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alters plant growth and developmentJ. Biol. Chem.280(41),34888-34899(2005)