Dorsomorphin
Cat. No.：YN420164
CAS No. ：866405-64-3
规格
价格(RMB)
库存
| 产品名称: | Dorsomorphin |
| CAS No.: | 866405-64-3 |
| Chemical Name: | 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine |
| Synonyms: | Compound C; BML-275 |
| 分子量: | 399.49 |
| 分子式: | C₂₄H₂₅N₅O |
| SMILES: | C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dorsomorphin (Compound C) 是一种选择性，ATP 竞争性的AMPK抑制剂 (在没有 AMP 的情况下，Ki为 109 nM)。Dorsomorphin 选择性抑制 BMP I 型受体ALK2，ALK3和ALK6。Dorsomorphin 诱导自噬 (autophagy) 作用。 |
| IC50和靶点: | [{name:"AMPK:109 nM (Ki)'}, 'ACVR1', 'BMPR1A', 'ALK6', 'Autophagy'] |
| In Vitro: | |
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| Solvent & Solubility: |
Zhou, G., Myers, R., Li, Y., et al.Role of AMP-activated protein kinase in mechanism of metformin actionJ. Clin. Invest.108(8),1167-1174(2001)
Yu, P.B., Hong, C.C., Sachidanandan, C., et al.Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolismNat. Chem. Biol.4(1),33-41(2008)
Vucicevic, L., Misirkic, M., Janjetovic, K., et al.Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathwayAutophagy7(1),40-50(2011)
