α-Zearalenol
Cat. No.：YN483355
CAS No. ：36455-72-8
| 产品名称: | α-Zearalenol |
| CAS No.: | 36455-72-8 |
| Chemical Name: | (3S,7R,11E)-3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one |
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| 分子量: | 320.38 |
| 分子式: | C₁₈H₂₄O₅ |
| SMILES: | OC1=C2C(O[C@H](CCC[C@@H](CCC/C=C/C2=CC(O)=C1)O)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | α-Zearalenol 是一种对雌激素受体 (ER) 具有高亲和力的霉菌毒素,_x000D_ α-Zearalenol 是 zearalenone (ZEN) 的衍生物，由于其异种雌激素效应可引起动物的生殖障碍。 |
| IC50和靶点: | |
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Zinedine, A., Soriano, J.M., Moltó, J.C., et al.Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxinFood Chem. Toxicol.45(1),1-18(2007)
Ueno, Y., and Tashiro, F.α-Zearalenol, a major hepatic metabolite in rats of zearalenone, an estrogenic mycotoxin of Fusarium speciesJ. Biochem.89(2),563-571(1981)
Kiang, D.T., Kennedy, B.J., Pathre, S.V., et al.Binding characteristics of zearalenone analogs to estrogen receptorsCancer Res.38(11 Pt 1),3611-3615(1978)
Mirocha, C.J., Pathre, S.V., Behrens, J., et al.Uterotropic activity of cis and trans isomers of zearalenone and zearalenolAppl. Environ. Microbiol.35(5),986-987(1978)
Filannino, A., Stout, T.A.E., Gadella, B.M., et al.Dose-response effects of estrogenic mycotoxins (zearalenone, alpha- and beta-zearalenol) on motility, hyperactivation and the acrosome reaction of stallion spermReprod. Biol. Endocrinol.9,134(2011)
Wang, H., Camargo Rodriguez, O., and Memili, E.Mycotoxin α-zearalenol impairs the quality of preimplantation porcine embryosJ. Reprod. Dev.58(3),338-343(2012)
