Brilanestrant
Cat. No.：YN480935
CAS No. ：1365888-06-7
规格
价格(RMB)
库存
| 产品名称: | Brilanestrant |
| CAS No.: | 1365888-06-7 |
| Chemical Name: | (2E)-3-[4-[(1E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)-1-buten-1-yl]phenyl]-2-propenoic acid |
| Synonyms: | ARN-810; GDC-0810 |
| 分子量: | 446.90 |
| 分子式: | C₂₆H₂₀ClFN₂O₂ |
| SMILES: | O=C(O)/C=C/C1=CC=C(/C(C2=CC3=C(NN=C3)C=C2)=C(C4=CC=C(F)C=C4Cl)/CC)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brilanestrant (ARN-810; GDC-0810) 是一种可口服的，选择性的雌激素降能器 (selective estrogen receptor degrader)，IC50值为 0.7 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lai, A., Kahraman, M., Govek, S., et al.Identification of GDC-0810 (ARN-810), an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenograftsJ. Med. Chem.58(12),4888-4904(2015)
