Otenzepad
Cat. No.：YN320139
CAS No. ：102394-31-0
| 产品名称: | Otenzepad |
| CAS No.: | 102394-31-0 |
| Chemical Name: | 11-[2-[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one |
| Synonyms: | AF-DX 116 |
| 分子量: | 421.54 |
| 分子式: | C₂₄H₃₁N₅O₂ |
| SMILES: | O=C1NC2=CC=CN=C2N(C(CN3C(CN(CC)CC)CCCC3)=O)C4=CC=CC=C14 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Otenzepad (AF-DX 116) 是一种选择性的、竞争性的M2 毒蕈碱乙酰胆碱受体拮抗剂，对兔外周肺和大鼠心脏的IC50值分别为 640 nM 和 386 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Doods, H.N., Mathy, M.-J., Davidesko, D., et al.Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptorsJ. Pharmacol. Exp. Ther.242(1),257-262(1987)
Bognar, I.T., Beinhauer, B., Kann, P., et al.Different muscarinic receptors mediate autoinhibition of acetylcholine release and vagally-induced vasoconstriction in the rat isolated perfused heartNaunyn Schmiedebergs Arch. Pharmacol.341(4),279-287(1990)
Hata, T., Itoh, E., Funakami, Y., et al.Blood pressure and heart rate are increased by AF-DX 116, a selective M2 antagonist, in autonomic imbalanced and hypotensive rats caused by repeated cold stressJpn. J. Pharmacol.85(3),313-321(2001)
