VU0467154
Cat. No.：YN320450
CAS No. ：1451993-15-9
| 产品名称: | VU0467154 |
| CAS No.: | 1451993-15-9 |
| Chemical Name: | 5-amino-3,4-dimethyl-N-[[4-[(trifluoromethyl)sulfonyl]phenyl]methyl]-thieno[2,3-c]pyridazine-6-carboxamide |
| Synonyms: | VU 0467154 |
| 分子量: | 444.45 |
| 分子式: | C₁₇H₁₅F₃N₄O₃S₂ |
| SMILES: | O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NCC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VU0467154 是一种 M4 毒蕈碱的乙酰胆碱受体 (M4 muscarinic acetylcholine receptor (mAChR)) 的正向调节剂，能够增强小鼠，人和食蟹猴 M4 受体对乙酰胆碱的反应，pEC50值分别为 7.75，6.2 和 6。 |
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Bubser, M., Bridges, T.M., Dencker, D., et al.Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodentsACS Chem. Neurosci.5(10),920-942(2014)
Pancani, T., Foster, D.J., Moehle, M.S., et al.Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 miceProc. Natl. Acad. Sci. USA112(45),14078-14083(2015)
