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Arecoline hydrobromide

Cat. No.:YN321517

  • CAS No. :300-08-3

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    • 产品名称: Arecoline hydrobromide
      CAS No.: 300-08-3
      Chemical Name: 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, monohydrobromide
      Synonyms:氢溴酸槟榔碱; Arecoline bromide
      分子量:236.11
      分子式:C₈H₁₄BrNO₂
      SMILES:O=C(C1=CCCN(C)C1)OC.Br
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Arecoline 氢溴酸盐 (Arecoline bromide) 是毒蕈碱乙酰胆碱受体(mAChR)激动剂。
      IC50和靶点:
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      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Okamoto, H., Prestwich, S.A., Asai, S., et al.Muscarinic agonist potencies at three different effector systems linked to the M2 or M3 receptor in longitudinal smooth muscle of guinea-pig small intestineBr. J. Pharmacol.135(7),1765-1775(2002)

      Thomas, R.L., Langmead, C.J., Wood, M.D., et al.Contrasting effects of allosteric and orthosteric agonists on M1 muscarinic acetylcholine receptor internalization and down-regulationJ. Pharmacol. Exp. Ther.331(3),1086-1095(2009)

      Heinrich, J.N., Butera, J.A., Carrick, T., et al.Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonistsEur. J. Pharmacol.605(1-3),53-56(2009)

      Garssen, J., Van Loveren, H., Gierveld, C.M., et al.Functional characterization of muscarinic receptors in murine airwaysBr. J. Pharmacol.109,53-60(1993)

      Ikeda, Y., and Kanai, A.Urotheliogenic modulation of intrinsic activity in spinal cord-transected rat bladders: Role of mucosal muscarinic receptorsAm. J. Physiol. Renal Physiol.295,F454-F461(2008)

      Bratt, A.M., Kelly, M.E., Domeney, A.M., et al.Acute and chronic arecoline: Effects on a scopolamine-induced deficit in complex maze learningPharmacol. Biochem. Behav.53(3),713-721(1996)

      Morley, J.E., Farr, S.A., and Flood, J.F.Antibody to amyloid β protein alleviates impaired acquisition, retention, and memory processing in SAMP8 miceNeurobiol. Learn. Mem.78,125-138(2002)

      Christie, J.E., Shering, A., Ferguson, J., et al.Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementiaBr. J. Psychiatry138,46-50(1981)

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