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Pilocarpine Hydrochloride

Cat. No.:YN321565

  • CAS No. :54-71-7

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Pilocarpine Hydrochloride
      CAS No.: 54-71-7
      Chemical Name: (3S,4R)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone, monohydrochloride
      Synonyms:盐酸毛果芸香碱
      分子量:244.72
      分子式:C₁₁H₁₇ClN₂O₂
      SMILES:CN1C(C[C@@H](COC2=O)[C@@H]2CC)=CN=C1.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Pilocarpine Hydrochloride 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Vanderheyden, P., Gies, J.-P., Ebinger, G., et al.Human M1-, M2- and M3-muscarinic cholinergic receptors: Binding characteristics of agonists and antagonistsJ. Neurol. Sci.97(1),67-80(1990)

      Renzi, A., Colombari, E., Mattos Filho, T.R., et al.Involvement of the central nervous system in the salivary secretion induced by pilocarpine in ratsJ. Dent. Res.72(11),1481-1484(1993)

      Lorenzetti, O.J.The influence of epinephrine and pilocarpine upon intraocular pressure following single and combination installationOphthal. Res.2(6),328-336(1971)

      Kokate, T.G., Cohen, A.L., Karp, E., et al.Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in miceNeuropharmacology35(8),1049-1056(1996)

      Ma, L., Wang, L., Yang, F., et al.Disease-modifying effects of RHC80267 and JZL184 in a pilocarpine mouse model of temporal lobe epilepsyCNS Neurosci. Ther.20(10),905-915(2014)

      Smolders, I., Khan, G.M., Manil, H., et al.NMDA receptor-mediated pilocarpine-induced seizures: Characterization in freely moving rats by microdialysisBr. J. Pharmacol.121(6),1171-1179(1997)

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