LC3-mHTT-IN-AN1
Cat. No.：YN280052
CAS No. ：486443-73-6
| 产品名称: | LC3-mHTT-IN-AN1 |
| CAS No.: | 486443-73-6 |
| Chemical Name: | 5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one |
| Synonyms: | |
| 分子量: | 411.04 |
| 分子式: | C₁₅H₉Br₂NO₃ |
| SMILES: | BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LC3-mHTT-IN-AN1 (Compound AN1) 是一种mHTT-LC3连接化合物，LC3-mHTT-IN-AN1 与突变型亨廷顿蛋白 (mHTT) 和 LC3B 相互作用，但不与 wtHTT 或无关的对照蛋白相互作用。LC3-mHTT-IN-AN1 以等位基因选择性的方式降低了亨廷顿病 (HD) 小鼠神经元中mHTT水平。 |
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| Solvent & Solubility: |
Li, Z., Wang, C., Wang, Z., et al.Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compoundsNature575(7781),203-209(2019)
