Ritanserin
Cat. No.：YN320343
| 产品名称: | Ritanserin |
| CAS No.: | 87051-43-2 |
| Chemical Name: | 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one |
| Synonyms: | R 55667 |
| 分子量: | 477.57 |
| 分子式: | C₂₇H₂₅F₂N₃OS |
| SMILES: | CC1=C(C(N(C=CS2)C2=N1)=O)CCN(CC/3)CCC3=C(C4=CC=C(F)C=C4)\C5=CC=C(F)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ritanserin (R 55667) 是一种高效、相对选择性、可口服、长效的5-HT2受体拮抗剂，IC50值为 0.9 nM，对组胺 Histamine H1，多巴胺 Dopamine D2，肾上腺素 Adrenergic α1，Adrenergic α2受体的活性较弱。 |
| IC50和靶点: | [{name:"5-HT2 Receptor:0.9 nM (IC50)"},{name: "H1 Receptor:35 nM (IC50)"},{name: "D2 Receptor:70 nM (IC50)"},{name: "Adrenergic α1:97 nM (IC50)"},{name: "Adrenergic α2:150 nM (IC50)"}] |
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Janssen, P.A.Pharmacology of potent and selective S2-serotonergic antagonistsJ. Cardiovasc. Pharmacol.7(Suppl 7),S2-11(1985)
Leysen, J.E., Gommeren, W., Van Gompel, P., et al.Receptor-binding properties in vitro and in vivo of ritanserin: A very potent and long acting serotonin-S2 antagonistMol. Pharmacol.27(6),600-611(1985)
Watanabe, Y., Usui, H., Kobayashi, S., et al.Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivativesJ. Med. Chem.35(1),189-194(1992)
