Doxylamine-d
Cat. No.：YN322921
| 产品名称: | Doxylamine-d |
| CAS No.: | 869497-75-6 |
| Chemical Name: | 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methyl-piperazine (2Z)-2-Butenedioate; VUF 6002 Maleate, VUF6002 maleate |
| Synonyms: | VUF6002 maleate |
| 分子量: | 394.81 |
| 分子式: | C17H19ClN4O5 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNJ10191584 (VUF6002) maleate (compound 40) 是具有口服活性的、选择性 histamineH4受体拮抗剂，Ki值为 26 nM。JNJ10191584 maleate 对 H4受体的选择性是 H3受体的 540 倍，对 H3受体的Ki值为 14.1 μM。JNJ10191584 maleate 抑制嗜酸性粒细胞和肥大细胞的趋化作用，IC50值分别为 530 nM 和 138 nM。 |
| IC50和靶点: | [{name:"Human H4 Receptor:26 nM (Ki)"},{name: "human H3 receptor:14.1 μM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Varga, C. et al.: Eur. J. Pharmacol., 522, 130 (2005)
