Asenapine maleate
Cat. No.：YN320426
CAS No. ：85650-56-2
| 产品名称: | Asenapine maleate |
| CAS No.: | 85650-56-2 |
| Chemical Name: | (3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-Butenedioate; trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole; Org 5222 |
| Synonyms: | 阿塞那平马来酸盐; Org 5222 maleate |
| 分子量: | 401.84 |
| 分子式: | C₂₁H₂₀ClNO₅ |
| SMILES: | CN1C[C@]2([H])C3=CC=CC=C3OC4=CC=C(Cl)C=C4[C@]2(C1)[H].O=C(O)/C=C\C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Asenapine maleate是5-HT(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) 和D2的拮抗剂，Ki值分别为 0.03-4.0 nM, 1.3 nM。同时也是一种抗精神病药物。 |
| IC50和靶点: | [{name:"sPLA2:2.5 nM (Ki)"},{name: "5-HT2A Receptor:0.06 nM (Ki)"},{name: "5-HT2C Receptor:0.03 nM (Ki)"},{name: "5-HT7 Receptor:0.13 nM (Ki)"},{name: "D2 Receptor:1.3 nM (Ki)"},{name: "D3 Receptor:0.42 nM (Ki)"},{name: "D4 Receptor:1.1 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tarazi. F.I., et al.: Drugs. Today., 45, 865 (2009)
Boboaca, S.D., et al.: Int. J. Molec. Sci., 12, 4348 (2011)
Audinot, V., et al.: Neuropsycopharmacol., 25, 410 (2001)
