Quetiapine
Cat. No.：YN320882
CAS No. ：111974-69-7
| 产品名称: | Quetiapine |
| CAS No.: | 111974-69-7 |
| Chemical Name: | 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol; |
| Synonyms: | 喹硫平; ICI204636 |
| 分子量: | 383.51 |
| 分子式: | C₂₁H₂₅N₃O₂S |
| SMILES: | OCCOCCN(CC1)CCN1C2=NC3=CC=CC=C3SC4=C2C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Quetiapine (ICI204636) 是一种5-HT受体激动剂，对人5-HT1A的pEC50值为 4.77。Quetiapine 是多巴胺受体 (dopamine receptor) 拮抗剂，对人D2的pIC50值为 6.33。Quetiapine 对人D2，HT1A，5-HT2A，5-HT2C受体具有中高等亲和力，pKi值为 7.25，5.74，7.54，5.55。具有抗抑郁和抗焦虑作用。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:5.74 (pKi)"},{name: "5-HT2A Receptor:7.54 (pKi)"},{name: "5-HT2C Receptor:5.55 (pKi)"},{name: "D2 Receptor:7.25 (pKi)"},{name: "5-HT1A Receptor:4.77 (pEC50)"},{name: "D2 Receptor:6.33 (pIC50)"}] |
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| Solvent & Solubility: |
Cutler, A., et al.: J. Clin. Psych., 70, 526 (2009)
Kapur, S., et al.: Arch. Gen. Psych., 57, 553 (2000)
Peuskens, J. & Link, C.: Acta. Psych. Scand., 96, 265 (1997)
