SB-269970 hydrochloride
Cat. No.：YN320968
CAS No. ：261901-57-9
| 产品名称: | SB-269970 hydrochloride |
| CAS No.: | 261901-57-9 |
| Chemical Name: | 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-phenol, monohydrochloride |
| Synonyms: | SB-269970A |
| 分子量: | 388.95 |
| 分子式: | C₁₈H₂₉ClN₂O₃S |
| SMILES: | OC1=CC=CC(S(=O)(N2[C@@H](CCN3CCC(C)CC3)CCC2)=O)=C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SB269970 hydrochloride (SB-269970A) 是5-HT7受体拮抗剂，pKi为 8.3，比对其它受体的抑制性高 50 倍以上。 |
| IC50和靶点: | [{name:"5-HT7 Receptor:8.3 (pKi)"}] |
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| Solvent & Solubility: |
Lovell, P.J., Bromidge, S.M., Dabbs, S., et al.A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970)J. Med. Chem.43(3),342-345(2000)
Foong, J.P.P., and Bornstein, J.C.5-HT antagonists NAN-190 and SB 269970 block α2-adrenoceptors in the guinea pigNeuroreport20(3),325-330(2009)
Nikiforuk, A., Kos, T., Fijal, K., et al.Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in ratsPLoS One8(6),1-12(2013)
