Brexpiprazole
Cat. No.：YN321034
CAS No. ：913611-97-9
| 产品名称: | Brexpiprazole |
| CAS No.: | 913611-97-9 |
| Chemical Name: | 7-[4-(4-benzo[b]thien-4-yl-1-piperazinyl)butoxy]-2(1H)-quinolinone |
| Synonyms: | 依匹哌唑; OPC-34712 |
| 分子量: | 433.57 |
| 分子式: | C₂₅H₂₇N₃O₂S |
| SMILES: | O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5)C5=CC=C4)CC3)=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brexpiprazole (OPC-34712)，一种非典型抗精神病药，是人5-HT1A和多巴胺受体的部分激动剂，Ki分别为0.12 nM 和 0.3 nM。Brexpiprazole也是5-HT2A受体的拮抗剂，Ki为 0.47 nM。 |
| IC50和靶点: | [{name:"5-HT1A Receptor:0.12 nM (Ki)"},{name: "5-HT2A Receptor:0.47 nM (Ki)"},{name: "D2L Receptor:0.3 nM (Ki)"},{name: "human noradrenergic α1B:0.17 nM (Ki)"},{name: "human noradrenergic α2C:0.59 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Maeda, K., Sugino, H., Akazawa, H., et al.Brexpiprazole I: In vitro and in vivo characterization of a novel serotonin-dopamine activity modulatorJ. Pharmacol. Exp. Ther.350(3),589-604(2014)
Maeda, K., Lerdrup, L., Sugino, H., et al.Brexpiprazole II: Antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulatorJ. Pharmacol. Exp. Ther.350(3),605-614(2014)
