Org-12962 hydrochloride
Cat. No.：YN321262
| 产品名称: | Org-12962 hydrochloride |
| CAS No.: | 210821-63-9 |
| Chemical Name: | 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-piperazine, monohydrochloride |
| Synonyms: | Org 12962 hydrochloride |
| 分子量: | 302.12 |
| 分子式: | C₁₀H₁₂Cl₂F₃N₃ |
| SMILES: | FC(C1=C(Cl)N=C(N2CCNCC2)C=C1)(F)F.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Org 12962 hydrochloride 是一种有效的、选择性的 5-HT2C受体激动剂，对 5-HT2C，5-HT2A，5-HT2B的pEC50分别为 7.01、6.38 和 6.28。Org 12962 hydrochloride 在焦虑大鼠的模型中显示出缓解作用。 |
| IC50和靶点: | [{name:"5-HT2C Receptor:7.01 (pEC50)"},{name: "5-HT2A Receptor:6.38 (pEC50)"},{name: "5-HT2B Receptor:6.28 (pEC50)"}] |
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Porter, R.H.P., Benwell, K.R., Lamb, H., et al.Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cellsBr. J. Pharmacol.128(1),13-20(1999)
Jenck, F., Moreau, J.-L., Berendsen, H.H.G., et al.Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in ratsEur. Neuropsychopharmacol.8(3),161-168(1998)
