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Chlorpromazine hydrochloride

Cat. No.:YN321485

  • CAS No. :69-09-0

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    • 参考文献
    • 产品名称: Chlorpromazine hydrochloride
      CAS No.: 69-09-0
      Chemical Name: 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, monohydrochloride
      Synonyms:盐酸氯丙嗪
      分子量:355.33
      分子式:C₁₇H₂₀Cl₂N₂S
      SMILES:CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Chlorpromazine Hydrochloride 是D2,5HT2A,钾通道和钠通道的拮抗剂。 Chlorpromazine Hydrochloride 与 D2 和 5HT2A 结合的Ki分别为363 nM和8.3 nM。
      IC50和靶点:
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    • Seeman, P., and Tallerico, T.Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptorsMol. Psychiatry3(2),123-134(1998)

      Seeman, P., Corbett, R., and Van Tol, H.H.Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptorsNeuropsychopharmacology16(2),93-110(1997)

      Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3),519-526(2003)

      Terry, A.V., Jr., Warner, S.E., Vandenhuerk, L., et al.Negative effects of chronic oral chlorpromazine and olanzapine treatment on the performance of tasks designed to assess spatial learning and working memory in ratsNeuroscience156(4),1005-1016(2008)

      Gylys, J.A., Doran, K.M., and Buyniski, J.P.Antagonism of cisplatin induced emesis in the dogRes. Commun. Chem. Pathol. Pharmacol.23(1),61-68(1979)

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