Pindolol
Cat. No.：YN321594
| 产品名称: | Pindolol |
| CAS No.: | 13523-86-9 |
| Chemical Name: | 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol |
| Synonyms: | 吲哚洛尔; LB-46 |
| 分子量: | 248.32 |
| 分子式: | C₁₄H₂₀N₂O₂ |
| SMILES: | OC(CNC(C)C)COC1=CC=CC2=C1C=CN2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pindolol (LB-46) 是一种非选择性β-阻断剂, 局部的β-肾上腺素能受体激动剂活性, 也作为5-HT1A受体部分拮抗剂 (Ki=33nM)。 |
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Hicks, P.E., Cavero, I., Manoury, P., et al.Comparative analysis of beta-1 adrenoceptor agonist and antagonist potency and selectivity of cicloprolol, xamoterol and pindololJ. Pharmacol. Exp. Ther.242(3),1025-1034(1987)
Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al.Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cellsN.-S. Arch. Pharmacol.369(2),151-159(2004)
Krushinski, J.H., Jr., Schaus, J.M., Thompson, D.C., et al.Indoloxypropanolamine analogues as 5-HT1A receptor antagonistsBioorg. Med. Chem. Lett.17(20),5600-5604(2007)
Lubawski, I., and Wale, J.Studies with LB 46, a new β-receptor blocking drugEur. J. Pharmacol.6(3),345-348(1969)
Antonaccio, M.J., High, J., DeForrest, J.M., et al.Antihypertensive effects of 12 beta adrenoceptor antagonists in conscious spontaneously hypertensive rats: Relationship to changes in plasma renin activity, heart rate and sympathetic nerve functionJ. Pharmacol. Exp. Ther.238(1),378-387(1986)
