Gamma-Mangostin

Cat. No.：YN321742

CAS No. ：31271-07-5

产品名称:	Gamma-Mangostin
CAS No.:	31271-07-5
Chemical Name:	1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
Synonyms:	γ-Mangostin
分子量:	396.43
分子式:	C₂₃H₂₄O₆
SMILES:	O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(O)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 98%

产品描述:	Gamma-Mangostin 是一种新颖的竞争性5-HT2A receptors拮抗剂，从药用植物Garcinia mangostana的果壳中提纯。Gamma-Mangostin 是一种运甲状腺素蛋白 (TTR) 原纤维化抑制剂，它与甲状腺素 (T4) 结合位点结合并稳定了 TTR 四聚体。Gamma-Mangostin 抑制 [3H]-spiperone 与培养的大鼠主动脉心肌细胞结合 (IC50= 3.5 nM)，并降低大鼠冠状动脉对 5-HT2A 的灌注压力反应 (IC50= 0.32 µM)。
IC50和靶点:
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Li, X.Comparative study of 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH•) scavenging capacity of the antioxidant xanthones familyChemistry Select3(46),13081-13086(2018)
Chi, X.-Q., Zi, C.-T., Li, H.-M., et al.Design, synthesis and structure–activity relationships of mangostin analogs as cytotoxic agentsRSC Adv.8(72),41377-41388(2018)
Bumrungpert, A., Kalpravidh, R.W., Chuang, C.-C., et al.Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned mediaJ. Nutr.140(4),842-847(2010)
Wang, A., Zhou, F., Li, D., et al.γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axisToxicol. Appl. Pharmacol.363,142-153(2019)